Understanding how Listeria bacteria survive inside human cells
Official title: Identification and Characterization of Genes Required for Listeria monocytogenes Cytosolic Survival
Funded at University of Wisconsin-Madison · NIH-11113986 · Data updated 2026-11-12
This study is looking at how the Listeria bacteria manage to survive and thrive inside human cells, which usually aren't friendly to germs, and the findings could help create better treatments for infections like Listeriosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | June 12, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $701,919 |
| NIH project number | 5R01AI184369-02 |
| Project ID | NIH-11113986 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals at risk for Listeriosis, such as pregnant women, the elderly, and those with weakened immune systems.
✕Less likely to help
Patients who are not at risk for Listeriosis or do not have compromised immune systems may not receive direct benefits from this research.
What this research studies
This research investigates the mechanisms by which the Listeria monocytogenes bacteria adapt to survive in the cytosol of human cells, which is typically a hostile environment for pathogens. By conducting genetic screens, the researchers aim to identify specific genes that are crucial for the bacteria's survival and virulence. The study focuses on understanding the stress responses and metabolic adaptations that allow Listeria to thrive, which could lead to new insights into bacterial infections and potential treatments. Patients may benefit from this research as it could inform the development of targeted therapies against Listeriosis and similar infections.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for Listeriosis and enhance our understanding of bacterial infections.
How similar studies have gone: Other research has shown success in understanding bacterial survival mechanisms, making this approach promising but still exploring novel aspects.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Sauer, John-Demian — University of Wisconsin-Madison
- Study coordinator: Sauer, John-Demian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.