Understanding How Listeria Bacteria Cause Brain Infections
Invasion of the enteric nervous system by neurotropic Listeria monocytogenes
This research explores how Listeria bacteria, which can cause severe brain infections, might begin their journey in the intestines before reaching the brain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-11111404 on NIH RePORTER |
What this research studies
Listeria monocytogenes can cause two types of serious brain infections in people: widespread meningitis and a more focused brainstem infection called rhombencephalitis. While meningitis often affects those with weakened immune systems, rhombencephalitis typically occurs in young, otherwise healthy individuals, suggesting a different infection pathway. This project focuses on the idea that the specific features of Listeria that cause rhombencephalitis might be active in the intestines first, rather than directly in the brain. Early findings suggest that if the bacteria bypass the gut, they do not spread to the brain, highlighting the gut's potential role. By understanding this initial gut invasion, we hope to uncover new ways to prevent or treat these serious brain infections.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit individuals susceptible to Listeria brain infections, particularly rhombencephalitis.
Not a fit: Patients not at risk for Listeria infections, or those with other types of brain infections, would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for preventing or treating severe Listeria brain infections, especially rhombencephalitis.
How similar studies have performed: Preliminary data from this team and findings from other groups support the idea that the gut plays a crucial role in how Listeria causes rhombencephalitis, making this a promising area of focus.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: D'orazio, Sarah E. F. — University of Kentucky
- Study coordinator: D'orazio, Sarah E. F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.