Understanding how lipids influence receptor signaling in cells
Official title: Lipid dependent GPCR signaling: Thermodynamics and mechanisms
Funded at University of Delaware · NIH-11056118 · Data updated 2026-11-12
This study is looking at how fats in our cells can influence important receptors that help control many body functions, which could lead to new ways to improve treatments for various health conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Delaware NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | April 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $389,285 |
| NIH project number | 5R35GM153273-02 |
| Project ID | NIH-11056118 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve GPCR signaling, such as cardiovascular diseases, neurological disorders, or metabolic syndromes.
✕Less likely to help
Patients with conditions unrelated to GPCR signaling or those who do not have access to the research facilities may not benefit from this research.
What this research studies
This research investigates the role of lipids in regulating the function of G-protein coupled receptors (GPCRs), which are crucial for many cellular processes and are significant pharmaceutical targets. By examining how different lipid compositions affect the activation of receptors like the A2A adenosine receptor, the research aims to quantify the relationship between lipids and receptor signaling. The approach includes computational simulations and biological models to explore these mechanisms in various cellular environments, potentially leading to insights applicable across different GPCRs and tissues.
Why it matters
Potential benefit: If successful, this research could lead to improved drug development strategies targeting GPCRs, enhancing treatment options for various diseases.
How similar studies have gone: Other research has shown promising results in understanding GPCR signaling and lipid interactions, indicating that this approach has potential for significant advancements.
Where this research is happening
-
University of Delaware
Newark, United States Active
Researchers
- Principal investigator: Lyman, Edward Ray — University of Delaware
- Study coordinator: Lyman, Edward Ray
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.