Understanding how lipids in primary cilia affect metabolic health
Official title: Deciphering the lipid composition of primary cilia in human metabolic disease
Funded at Stanford University · NIH-10932139 · Data updated 2026-11-12
This study is looking at tiny structures on our cells called primary cilia to see how their makeup affects important processes in our bodies, like how we manage insulin and fat, which could help us find better ways to treat obesity and related health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 20, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $387,172 |
| NIH project number | 5DP5OD036155-02 |
| Project ID | NIH-10932139 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals over 21 years old who are affected by metabolic diseases, particularly those related to obesity.
✕Less likely to help
Patients with metabolic conditions unrelated to GPCR signaling or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the role of primary cilia, small organelles on cell surfaces, in human metabolic diseases by focusing on how their lipid composition influences signaling pathways. The study aims to explore how G protein-coupled receptors (GPCRs) located in these cilia transmit signals that regulate important metabolic processes, such as insulin secretion and fat cell formation. By developing innovative tools to visualize and manipulate lipids in primary cilia, the research seeks to uncover mechanisms that could lead to better understanding and treatment of obesity and related metabolic disorders.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapies for managing obesity and metabolic diseases.
How similar studies have gone: Previous research has shown promising results in understanding GPCR signaling in metabolic processes, indicating that this approach has potential for success.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Kinnebrew, Maia — Stanford University
- Study coordinator: Kinnebrew, Maia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.