Understanding how lipids are transported between cell membranes
Official title: Analysis of Bulk Lipid Transport at Membrane Contact Sites
Funded at University of Wisconsin-Madison · NIH-11141818 · Data updated 2026-11-12
This study is looking at special proteins that help move fats around inside cells, which is really important for keeping our cells healthy, and it's using fruit flies to see how problems with these proteins might be linked to diseases like Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | July 19, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $497,317 |
| NIH project number | 5R01GM155154-02 |
| Project ID | NIH-11141818 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients with non-neurological conditions or those not affected by lipid metabolism disorders may not benefit from this research.
What this research studies
This research investigates the role of bridge-like lipid transfer proteins (BLTPs) in the transport of lipids between organelle membranes, which is crucial for maintaining cellular function. Using a Drosophila model, the study aims to explore how disruptions in these proteins can lead to significant physiological and cellular changes. By examining the molecular and cellular functions of BLTPs, the research seeks to uncover their importance in health and disease, particularly in conditions like Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of lipid transport and its implications for diseases such as Alzheimer's, potentially paving the way for novel therapeutic strategies.
How similar studies have gone: While the specific focus on BLTPs is novel, similar research on lipid transport mechanisms has shown promise in understanding various diseases.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Bashirullah, Arash — University of Wisconsin-Madison
- Study coordinator: Bashirullah, Arash
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.