Understanding how lipids affect the nuclear envelope's structure and function
Defining the role of lipid metabolism in nuclear envelope identity and dynamics
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11126855
This study is looking at how fats and proteins work together to keep the protective layer around our DNA healthy and stable, especially when cells divide, which is important for keeping our genetic information safe.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11126855 on ClinicalTrials.gov |
What this research studies
This research investigates the role of lipid metabolism in maintaining the identity and dynamics of the nuclear envelope, which protects our genetic material. By using vertebrate tissue culture cells, the study aims to uncover how specific proteins and lipids interact to form and stabilize the nuclear envelope during cell division. The research will explore the mechanisms that target proteins to the nuclear envelope and how these proteins influence lipid composition and membrane remodeling. This work could provide insights into cellular processes that are crucial for maintaining genome integrity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions linked to nuclear envelope abnormalities or accelerated aging.
Not a fit: Patients with unrelated health issues or those not experiencing accelerated aging or nuclear envelope-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for addressing diseases related to nuclear envelope dysfunction, including certain cancers and age-related conditions.
How similar studies have performed: While the specific focus on lipid metabolism in the nuclear envelope is novel, related research has shown promising results in understanding cellular membrane dynamics.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BAHMANYAR, SHIRIN — YALE UNIVERSITY
- Study coordinator: BAHMANYAR, SHIRIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.