Understanding how lipids affect protein behavior and function
Genetically Encoded Lipidation to Manipulate Structure, Assembly, and Phase Behavior of Proteins
This study is looking at how adding fats to proteins can change how they work in our bodies, which could help us understand diseases better and find new ways to treat them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Syracuse University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project ID | NIH-10868601 on NIH RePORTER |
What this research studies
This research investigates the role of lipidation, a process where lipids are added to proteins, in influencing their structure and function. By genetically engineering bacteria to produce proteins with various lipid modifications, the study aims to create a library of lipidated proteins to explore how these changes affect cellular processes and disease mechanisms. Patients may benefit from insights gained into how lipidation impacts diseases, potentially leading to new therapeutic strategies. The research employs advanced genetic engineering techniques to systematically modify proteins and study their behavior in biological contexts.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to protein misfolding or dysfunction.
Not a fit: Patients with conditions unrelated to protein lipidation or those not affected by protein structure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases linked to protein dysfunction.
How similar studies have performed: While the approach of genetically modifying proteins is established, the specific focus on lipidation and its comprehensive study is relatively novel.
Where this research is happening
Syracuse, United States
- Syracuse University — Syracuse, United States (Active)
Researchers
- Principal investigator: Mozhdehi , Davoud — Syracuse University
- Study coordinator: Mozhdehi , Davoud
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.