Understanding how lipids affect ion channels in the brain
Lipid Modulation of Ligand-Gated Ion Channels
['FUNDING_OTHER'] · WASHINGTON UNIVERSITY · NIH-10870003
This study is looking at how certain fats in our body affect the way nerve signals are sent, which could help improve treatments for neurological conditions by giving us a better understanding of how these fats interact with important channels in our nerves.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10870003 on ClinicalTrials.gov |
What this research studies
This research investigates how certain lipids, like phospholipids and fatty acids, influence the activity of ion channels that are crucial for nerve signal transmission. By using advanced techniques such as mass spectrometry and functional analysis in model membranes, the researchers aim to uncover the specific ways these lipids bind to and modulate ion channels. This could lead to a better understanding of how neuroactive drugs work and how they can be improved for better therapeutic outcomes. Patients may benefit from insights gained about the interactions between lipids and ion channels, which could inform the development of new treatments for neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with neurological conditions that affect synaptic transmission.
Not a fit: Patients with conditions unrelated to synaptic transmission or those not affected by ion channel dysfunction may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to nerve signaling, such as epilepsy and other neurological disorders.
How similar studies have performed: Other research has shown promising results in understanding lipid modulation of ion channels, indicating that this approach has potential for significant advancements.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHENG, WAYLAND WING-LUN — WASHINGTON UNIVERSITY
- Study coordinator: CHENG, WAYLAND WING-LUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.