Understanding how lipids affect bone growth in the growth plate
Official title: Lipid metabolism in the growth plate
Funded at University of Maryland Baltimore · NIH-11009974 · Data updated 2026-11-12
This study is looking at how fat helps bone growth in kids and teens, especially during puberty, by checking how bone-building cells use fat for energy when they're growing fast.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | January 15, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $482,145 |
| NIH project number | 5R01AR083363-02 |
| Project ID | NIH-11009974 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and adolescents experiencing growth issues, particularly those with conditions affecting lipid metabolism.
✕Less likely to help
Patients with normal growth patterns and no underlying metabolic disorders may not benefit from this research.
What this research studies
This research investigates the role of lipid metabolism in the growth plate, which is crucial for bone growth. It focuses on how chondrocytes, the cells responsible for bone formation, utilize lipids for energy during periods of rapid growth, such as puberty. The study aims to explore the relationship between lipid availability and bone growth, particularly in conditions where lipid metabolism is disrupted. By examining the lipid content in different zones of the growth plate, the research seeks to uncover new insights into how energy supply affects bone development.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for growth disorders related to lipid metabolism.
How similar studies have gone: While lipid metabolism in the growth plate is not extensively studied, related research has shown that understanding metabolic pathways can lead to significant advancements in treating growth disorders.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Otsuru, Satoru — University of Maryland Baltimore
- Study coordinator: Otsuru, Satoru
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.