Understanding how lipids affect aging and Alzheimer's disease
Defining lipid droplet homeostasis in Alzheimer's disease and aging with high molecular specificity using mass spectrometry imaging and isomer resolved lipidomics
['FUNDING_R01'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-11058439
This study is looking at how fats in the body change as we age and how these changes might be linked to Alzheimer's disease, with the goal of finding ways to better understand and possibly help with brain health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11058439 on ClinicalTrials.gov |
What this research studies
This research investigates the role of lipids in aging and Alzheimer's disease by using advanced mass spectrometry imaging techniques. It aims to define what normal lipid levels are and how they fluctuate throughout life, particularly in relation to brain health. By creating detailed maps of lipid distribution in brain tissues, the study seeks to uncover how lipid imbalances contribute to Alzheimer's and related dementias. This approach could lead to better understanding and potential interventions for these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults and individuals at risk for Alzheimer's disease or related dementias.
Not a fit: Patients who are not experiencing cognitive decline or do not have risk factors for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease and improving healthspan in aging individuals.
How similar studies have performed: Other research has shown promising results in understanding lipid roles in various diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCOTT, ALISON J — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: SCOTT, ALISON J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: aging associated disease