Understanding how lipid nanoparticles affect the immune system
Official title: Immunogenicity of lipid nanoparticles
Funded at Cornell University · NIH-11037967 · Data updated 2026-11-12
This study is looking at how tiny particles used in some vaccines, like those for COVID-19, affect our immune system and whether they might cause any side effects, so we can better understand how these vaccines work for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | February 16, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $661,275 |
| NIH project number | 5R01AI178125-02 |
| Project ID | NIH-11037967 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have received LNP-based vaccines and are experiencing adverse effects.
✕Less likely to help
Patients who have not received LNP-based vaccines or those who do not experience any adverse effects may not benefit from this research.
What this research studies
This research investigates the immunogenicity of lipid nanoparticles (LNPs), which are used in vaccines, including those for COVID-19. The study aims to systematically analyze how these nanoparticles interact with the immune system and the potential adverse effects they may cause. By formulating different libraries of LNPs, the researchers will explore the immunological pathways involved and the relationship between LNP components and their immunogenicity. This could lead to a better understanding of the side effects associated with LNP-based vaccines.
Why it matters
Potential benefit: If successful, this research could improve the safety and efficacy of vaccines that utilize lipid nanoparticles.
How similar studies have gone: While there has been some research on the efficacy of LNPs, this investigation into their immunogenicity is relatively novel and has not been extensively studied in humans.
Where this research is happening
-
Cornell University
Ithaca, United States Active
Researchers
- Principal investigator: Jiang, Shaoyi — Cornell University
- Study coordinator: Jiang, Shaoyi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.