Understanding how lipid metabolism affects invasive ovarian cancer cells
Lipid Metabolism Switch Triggers Invasive and Chemoresistant Epithelial Ovarian Cancer Phenotype
This study is looking at how some ovarian cancer cells become tough and hard to treat with chemotherapy, and it aims to find out what makes these cells survive and grow, which could help develop better treatments for patients with this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-10893352 on NIH RePORTER |
What this research studies
This research investigates the complex nature of epithelial ovarian cancer (EOC), focusing on how certain cancer cells become invasive and resistant to chemotherapy. By analyzing tumor organoid cultures, the study aims to uncover the mechanisms behind the survival and proliferation of drug-resistant cancer cells, particularly polyploidal giant cancer cells. The researchers will explore how metabolic changes in these cells, triggered by stressors like nutrient deprivation and hypoxia, contribute to their aggressive behavior. This work seeks to provide insights that could lead to more effective treatments for EOC.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with epithelial ovarian cancer, particularly those experiencing treatment resistance.
Not a fit: Patients with non-epithelial ovarian cancers or those who are not currently undergoing treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that more effectively target and eliminate invasive and chemoresistant ovarian cancer cells.
How similar studies have performed: Previous research has shown promising results in understanding cancer cell metabolism and its role in treatment resistance, suggesting that this approach could yield valuable insights.
Where this research is happening
Providence, United States
- Brown University — Providence, United States (Active)
Researchers
- Principal investigator: Dawson, Michelle R — Brown University
- Study coordinator: Dawson, Michelle R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.