Understanding how lipid metabolism affects insulin action in skeletal muscle
Lands cycle and skeletal muscle insulin action
This study is looking at how fat processing in our muscles affects insulin resistance, which is important for people with type 2 diabetes, and it aims to find new ways to help improve insulin sensitivity, especially in those who are obese.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10874726 on NIH RePORTER |
What this research studies
This research investigates the role of lipid metabolism in skeletal muscle insulin resistance, a key factor in the development of type 2 diabetes. The study focuses on the Lands cycle, a process that may alter insulin receptor sensitivity in muscle tissues. By examining how obesity influences this cycle and insulin signaling, the researchers aim to identify potential therapeutic targets. The approach includes both genetic and pharmacological methods in animal models, as well as insights from human studies to understand the implications for insulin sensitivity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with obesity or those at risk of developing type 2 diabetes.
Not a fit: Patients who do not have insulin resistance or type 2 diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve insulin sensitivity and help manage or prevent type 2 diabetes.
How similar studies have performed: Previous research has shown promising results in understanding lipid metabolism's role in insulin action, indicating that this approach could lead to significant advancements.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Funai, Katsuhiko — University of Utah
- Study coordinator: Funai, Katsuhiko
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.