Understanding how lipid membranes affect hearing in cochlear hair cells
Official title: Investigating the role of lipid membrane in the cochlear hair cell mechanotransduction
Funded at Stanford University · NIH-11061363 · Data updated 2026-11-12
This study looks at how the tiny membranes in our ear cells help turn sound vibrations into electrical signals, which is essential for hearing, and it aims to find out more about how this process works to help develop new treatments for hearing loss as we age.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $194,599 |
| NIH project number | 5R21DC021027-03 |
| Project ID | NIH-11061363 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related hearing loss or impairment.
✕Less likely to help
Patients with hearing loss due to non-age-related factors, such as genetic conditions or acute injuries, may not benefit from this research.
What this research studies
This research investigates how lipid membranes influence the process by which sound vibrations are converted into electrical signals in cochlear hair cells, a critical function for hearing. By examining the role of lipid molecules and their interactions with proteins in the hair cells, the study aims to uncover the mechanisms behind hearing loss and deafness. The approach includes advanced techniques to analyze the mechanical properties of membranes and their effects on ion channels involved in hearing. Insights gained could lead to new treatments for age-related hearing impairments.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that improve hearing function and prevent hearing loss in aging populations.
How similar studies have gone: Previous research has shown promising results in understanding the role of lipid membranes in other mechanotransduction processes, suggesting potential for success in this area as well.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Sam George, Shefin — Stanford University
- Study coordinator: Sam George, Shefin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.