Understanding how lipid droplets affect metabolism in cells
Official title: Lipid droplets and the compartmentalization of subcellular metabolism
Funded at University of Minnesota · NIH-11011351 · Data updated 2026-11-12
This study is looking at how tiny fat storage structures in our cells, called lipid droplets, might play a role in conditions like non-alcoholic fatty liver disease and their links to Type 2 Diabetes and heart problems, especially as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $332,837 |
| NIH project number | 5R01DK132849-03 |
| Project ID | NIH-11011351 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults experiencing metabolic disorders, particularly those with or at risk for Type 2 Diabetes and non-alcoholic fatty liver disease.
✕Less likely to help
Patients without metabolic disorders or those who are not affected by lipid metabolism issues may not benefit from this research.
What this research studies
This research investigates the role of lipid droplets, which are essential for storing fats in cells, in the development of conditions like non-alcoholic fatty liver disease and its connection to diseases such as Type 2 Diabetes and cardiovascular issues. By using advanced techniques like organelle proteomics and super-resolution microscopy, the study aims to uncover how lipid droplets interact with other cell structures, particularly mitochondria, to influence metabolic processes. The findings could provide insights into how these interactions affect overall health, especially in aging populations.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating metabolic diseases linked to lipid metabolism.
How similar studies have gone: Previous research has shown promising results in understanding lipid metabolism and its implications for metabolic diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Mashek, Douglas G — University of Minnesota
- Study coordinator: Mashek, Douglas G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.