Understanding how lipid depletion affects protein translation in cells
Official title: Investigating the role of the RNA helicase F57B9.3 in translational regulation under conditions of lipid depletion
Funded at Ut Southwestern Medical Center · NIH-11069178 · Data updated 2026-11-12
This study is looking at how a certain protein helps cells adjust when they don't have enough fats, using tiny worms called C. elegans to learn more about how this affects the way cells make other proteins.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | December 1, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $40,127 |
| NIH project number | 1F31GM154433-01A1 |
| Project ID | NIH-11069178 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals interested in the biological mechanisms of nutrient metabolism and its implications for health.
✕Less likely to help
Patients with conditions unrelated to nutrient sensing or cellular metabolism may not benefit from this research.
What this research studies
This research investigates the role of a specific RNA helicase, F57B9.3, in regulating protein translation when cells experience lipid depletion. Using the model organism C. elegans, the study employs genetic techniques, including RNA interference and CRISPR/Cas-9 gene editing, to explore how lipid levels influence translation rates and the transcription factors involved. The research aims to uncover the mechanisms behind these processes, which could provide insights into cellular responses to nutrient availability.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cellular nutrient sensing and potentially lead to new therapeutic strategies for conditions related to nutrient imbalances.
How similar studies have gone: While the specific focus on lipid depletion and F57B9.3 is novel, related research has shown success in understanding nutrient sensing and translation regulation in other contexts.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Wall, Jordan Mccall — Ut Southwestern Medical Center
- Study coordinator: Wall, Jordan Mccall
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.