Understanding how lipid and lipoprotein imbalances affect sepsis outcomes
The Role and Mechanisms of Lipid and Lipoprotein Dysregulation in Sepsis
['FUNDING_R01'] · UNIVERSITY OF FLORIDA · NIH-10812415
This study is looking at how different types of fats in your blood, like cholesterol, affect how your body responds to serious infections called sepsis, with the goal of finding new ways to help patients recover better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-10812415 on ClinicalTrials.gov |
What this research studies
This research investigates the role of lipids and lipoproteins in sepsis, a severe response to infection that can lead to significant health complications. The study aims to understand how changes in cholesterol levels, particularly high-density lipoproteins (HDL) and low-density lipoproteins (LDL), impact the body's ability to respond to sepsis. By examining the mechanisms behind lipid dysregulation in sepsis patients, the research seeks to identify potential therapeutic targets that could improve patient outcomes. The approach includes analyzing lipid profiles and their relationship with organ function and recovery trajectories in critically ill patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with sepsis who are experiencing critical illness and may benefit from targeted lipid-based therapies.
Not a fit: Patients who are not critically ill or do not have a diagnosis of sepsis may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for sepsis, potentially reducing mortality and long-term complications for survivors.
How similar studies have performed: Previous research has indicated that lipid and lipoprotein levels play a significant role in sepsis outcomes, suggesting that this approach has the potential for meaningful advancements in treatment.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUIRGIS, FAHEEM W — UNIVERSITY OF FLORIDA
- Study coordinator: GUIRGIS, FAHEEM W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.