Understanding how lipid-anchored proteins interact with cell membranes
Dynamics of lipid-anchored proteins
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-10994147
This study is looking at how certain proteins that help control cell growth and communication work on cell membranes, and it hopes to find out how problems with these proteins might lead to diseases like cancer, which could help develop new treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10994147 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which lipid-anchored proteins, specifically those in the Ras superfamily, organize and function on cell membranes. It aims to uncover how these proteins, which play critical roles in cell growth and signaling, are influenced by their structural components, including a flexible linker region. By studying these proteins, the research seeks to identify how disruptions in their function can lead to diseases like cancer. The findings could pave the way for new therapeutic strategies targeting these proteins.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or developmental disorders linked to mutations in lipid-anchored proteins.
Not a fit: Patients with conditions unrelated to lipid-anchored proteins or those not affected by the Ras superfamily may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for diseases caused by dysfunctional lipid-anchored proteins.
How similar studies have performed: Previous research has shown promising results in targeting similar protein interactions, indicating potential for success in this area.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GORFE, ALEMAYEHU A. — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: GORFE, ALEMAYEHU A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers