Understanding how limb veins affect blood pressure regulation
The Human Cardiovascular Control: The Role of Limb Veins
['FUNDING_R01'] · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · NIH-10643837
This study is looking at how stretching the veins in your arms and legs affects your blood pressure and how certain substances in your body play a role in this process, all while checking how it works differently for men and women.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PENNSYLVANIA STATE UNIV HERSHEY MED CTR (nih funded) |
| Locations | 1 site (HERSHEY, UNITED STATES) |
| Trial ID | NIH-10643837 on ClinicalTrials.gov |
What this research studies
This research investigates how the distention of veins in the limbs influences blood pressure through a reflex known as the venous distension reflex (VDR). The study aims to explore the role of specific metabolites in this process and how they affect nerve activity and blood pressure responses. It will also examine how this reflex interacts with the body's baroreflex system, which helps regulate blood pressure during changes in posture. By studying these mechanisms in healthy individuals, the research seeks to provide insights into blood pressure regulation and its variations between genders.
Who could benefit from this research
Good fit: Ideal candidates for this research are healthy adults, particularly those interested in understanding blood pressure regulation and its physiological mechanisms.
Not a fit: Patients with existing cardiovascular diseases or those on medications affecting blood pressure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of blood pressure-related conditions.
How similar studies have performed: Previous research has shown promising results in understanding the role of venous distension in blood pressure regulation, making this study a continuation of established findings.
Where this research is happening
HERSHEY, UNITED STATES
- PENNSYLVANIA STATE UNIV HERSHEY MED CTR — HERSHEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CUI, JIAN — PENNSYLVANIA STATE UNIV HERSHEY MED CTR
- Study coordinator: CUI, JIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.