Understanding how LIMA1 affects the structure of tuft cells in the intestine
Official title: The Role of LIMA1 in the Formation of the Giant Core Actin Bundles in Tuft Cells
Funded at Vanderbilt University · NIH-10997063 · Data updated 2026-11-12
This study is looking at a protein called LIMA1 in special cells in your gut that help detect parasites and kickstart your immune system, to learn more about how these cells work and why they're important for keeping your gut healthy.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $34,314 |
| NIH project number | 1F31DK141157-01 |
| Project ID | NIH-10997063 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting gut health or those interested in understanding immune responses related to intestinal parasites.
✕Less likely to help
Patients without any gastrointestinal issues or those not affected by intestinal parasites may not benefit from this research.
What this research studies
This research investigates the role of LIMA1, a protein that helps form large bundles of actin filaments in tuft cells, which are specialized cells in the intestinal lining. Tuft cells play a crucial role in sensing intestinal parasites and triggering immune responses. By studying how LIMA1 influences the unique structure of these cells, researchers aim to fill gaps in knowledge about their function and importance in gut health. The approach involves examining the cellular architecture and molecular interactions within tuft cells to better understand their physiological roles.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gut health and immune responses, potentially improving treatments for intestinal diseases.
How similar studies have gone: While tuft cells are understudied, previous research on actin-binding proteins has shown promise in understanding cellular functions, indicating potential for success in this area.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Silverman, Jennifer — Vanderbilt University
- Study coordinator: Silverman, Jennifer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.