Understanding how LIM domain kinases regulate cell movement and shape
LIM domain kinases: regulation and substrate recognition
This study is looking at how certain proteins help control the shape and movement of cells, which is important for understanding diseases where these processes go wrong, and it could lead to better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11099276 on NIH RePORTER |
What this research studies
This research investigates the role of LIM domain kinases in regulating the actin cytoskeleton, which is crucial for cell shape, movement, and invasiveness. By examining how these kinases interact with other proteins and signaling pathways, the research aims to uncover the mechanisms that control cell behavior in response to various signals. The study employs biochemical and biophysical techniques to analyze these interactions and their implications for cellular processes. Patients may benefit from insights gained into diseases where cell movement and morphology are disrupted.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with conditions related to abnormal cell behavior, such as cancer or developmental disorders.
Not a fit: Patients with conditions unrelated to cell movement or cytoskeletal regulation may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions involving abnormal cell movement and morphology.
How similar studies have performed: Previous research has shown success in understanding similar signaling pathways and their implications for cell behavior, suggesting that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Boggon, Titus Jonathon — Yale University
- Study coordinator: Boggon, Titus Jonathon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.