Understanding how LIM domain kinases regulate actin remodeling in cells
LIM domain kinases: regulation and substrate recognition
This study is looking at how certain proteins help control the shape and movement of cells, which is important for understanding diseases where these processes go wrong, and it could lead to new insights that might help patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10906923 on NIH RePORTER |
What this research studies
This research investigates the role of LIM domain kinases in regulating the actin cytoskeleton, which is crucial for cell shape, movement, and invasiveness. By examining how these kinases are activated by RHO family GTPases and their subsequent effects on actin-depolymerizing proteins, the research aims to uncover the mechanisms that control cell behavior. The approach combines biophysical and biochemical techniques to explore the interactions and regulatory processes involved. Patients may benefit from insights gained into diseases where cell movement and morphology are disrupted.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with cancers or other diseases characterized by abnormal cell migration and morphology.
Not a fit: Patients with conditions unrelated to cell signaling or actin cytoskeleton dynamics may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions involving abnormal cell movement, such as cancer metastasis.
How similar studies have performed: Previous research has shown success in understanding the roles of similar kinases in cell signaling and movement, indicating that this approach has a solid foundation.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Boggon, Titus Jonathon — Yale University
- Study coordinator: Boggon, Titus Jonathon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.