Understanding how light-sensitive cells in the eye affect brain functions
Neurophysiology of Melanopsin Photoreceptors
This study is looking at special cells in your eyes that help control things like sleep and mood by responding to light, and it's for anyone interested in how these cells work and affect our daily lives.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10940094 on NIH RePORTER |
What this research studies
This research investigates intrinsically photosensitive retinal ganglion cells (ipRGCs) in the eye, which use a molecule called melanopsin to respond to light. By studying these cells, the research aims to uncover how they influence various brain functions, including the regulation of sleep, mood, and circadian rhythms. The team will utilize advanced techniques like patch-clamp electrophysiology to analyze the electrical responses of these cells in a controlled laboratory setting. The findings could enhance our understanding of how specific types of cells are adapted for their roles in the body.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing sleep disorders, mood disorders, or other conditions influenced by circadian rhythms.
Not a fit: Patients with no visual function or those not affected by circadian rhythm disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to circadian rhythm disruptions, mood disorders, and sleep issues.
How similar studies have performed: Previous research has shown promising results in understanding the role of ipRGCs in regulating circadian rhythms and mood, suggesting that this approach has potential for significant insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Do, Michael Tri Hoang — Boston Children's Hospital
- Study coordinator: Do, Michael Tri Hoang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.