Understanding how light affects pain in migraines using a rodent model

Neural Pathways of Light Aversion in a Rodent Model of Migraine

NIH-funded research University of Pennsylvania · NIH-10922765

This study is looking at how light can trigger pain in people with migraines by using a rodent model, and it aims to find new ways to help those who suffer from light sensitivity during their headaches.

Quick facts

Grant typeCareer grant
Study typeNIH-funded research
Funding institutionUniversity of Pennsylvania NIH-funded
Lab location1 site (Philadelphia, United States)
Project IDNIH-10922765 on NIH RePORTER

What this research studies

This research investigates the neural mechanisms that cause pain from light exposure in migraine sufferers by using a rodent model. The principal investigator, Dr. Eric Kaiser, will employ tailored light stimuli and advanced genetic techniques to explore how these factors influence pain pathways. The study aims to enhance our understanding of how light aversion occurs in migraines, which could lead to new treatment strategies. The research will also involve training in various scientific skills to ensure a comprehensive approach to the problem.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals who experience migraines and have light sensitivity as a symptom.

Not a fit: Patients who do not suffer from migraines or light sensitivity may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved treatments for individuals suffering from light sensitivity associated with migraines.

How similar studies have performed: While the specific approach may be novel, similar research has shown promise in understanding pain mechanisms in other contexts.

Where this research is happening

Philadelphia, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.