Understanding how ligand-gated ion channels work in cells
Official title: Ligand Gated Ion Channels Across Time and Space
Funded at Johns Hopkins University · NIH-10939700 · Data updated 2026-11-12
This study is looking at special channels in our cells that help them communicate and work properly, and it's for anyone interested in understanding how these channels can go wrong in certain diseases, with the hope of finding better treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $409,375 |
| NIH project number | 1R35GM154904-01 |
| Project ID | NIH-10939700 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to ion channel dysregulation, such as neurological disorders.
✕Less likely to help
Patients with conditions unrelated to ion channel function may not benefit from this research.
What this research studies
This research investigates ligand-gated ion channels (LGICs), which are crucial for cell communication and function. By examining how these channels open and close in response to environmental signals, the study aims to uncover the mechanisms that regulate their activity. The research utilizes advanced techniques like cryo-electron microscopy and electrophysiology to observe these processes at a molecular level. This knowledge could lead to better understanding of diseases linked to LGIC dysfunction and inform the development of targeted therapies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases caused by the malfunction of ion channels.
How similar studies have gone: Previous research has shown promising results in understanding ion channels, but this specific approach to studying LGICs is relatively novel.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Twomey, Edward C — Johns Hopkins University
- Study coordinator: Twomey, Edward C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.