Understanding how LEX-1 helps in DNA repair during reproduction
Official title: The role of conserved chromatin-associated LEX-1 in germline DNA repair
Funded at Harvard Medical School · NIH-11065109 · Data updated 2026-11-12
This study is looking at how a protein called LEX-1 helps fix DNA during the creation of reproductive cells, which could help us understand why some people experience infertility or miscarriages, and hopefully lead to better solutions for improving reproductive health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $39,418 |
| NIH project number | 1F31GM157766-01 |
| Project ID | NIH-11065109 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing infertility or recurrent miscarriages potentially linked to chromosomal issues.
✕Less likely to help
Patients without a history of infertility or miscarriages may not receive direct benefits from this research.
What this research studies
This research investigates the role of a specific protein, LEX-1, in the process of DNA repair during the formation of reproductive cells. By studying how LEX-1 influences the repair of double-strand breaks in DNA, the research aims to uncover the mechanisms that lead to proper chromosome segregation during meiosis. The approach involves examining genetic models to understand how disruptions in this process can lead to infertility and miscarriages. Patients may benefit from insights that could improve reproductive health and outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing infertility and miscarriages caused by chromosomal abnormalities.
How similar studies have gone: Other research has shown success in understanding chromatin dynamics and DNA repair mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Diaz Pacheco, Brianna — Harvard Medical School
- Study coordinator: Diaz Pacheco, Brianna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.