Understanding how LEX-1 helps in DNA repair during reproduction
The role of conserved chromatin-associated LEX-1 in germline DNA repair
['FUNDING_FELLOWSHIP'] · HARVARD MEDICAL SCHOOL · NIH-11065109
This study is looking at how a protein called LEX-1 helps fix DNA during the creation of reproductive cells, which could help us understand why some people experience infertility or miscarriages, and hopefully lead to better solutions for improving reproductive health.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD MEDICAL SCHOOL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11065109 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific protein, LEX-1, in the process of DNA repair during the formation of reproductive cells. By studying how LEX-1 influences the repair of double-strand breaks in DNA, the research aims to uncover the mechanisms that lead to proper chromosome segregation during meiosis. The approach involves examining genetic models to understand how disruptions in this process can lead to infertility and miscarriages. Patients may benefit from insights that could improve reproductive health and outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing infertility or recurrent miscarriages potentially linked to chromosomal issues.
Not a fit: Patients without a history of infertility or miscarriages may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing infertility and miscarriages caused by chromosomal abnormalities.
How similar studies have performed: Other research has shown success in understanding chromatin dynamics and DNA repair mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD MEDICAL SCHOOL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DIAZ PACHECO, BRIANNA — HARVARD MEDICAL SCHOOL
- Study coordinator: DIAZ PACHECO, BRIANNA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.