Understanding how leukemia stem cells grow and resist treatment
Official title: Regulation of Protein Synthesis in Leukemia Stem Cells
Funded at Ut Southwestern Medical Center · NIH-10932968 · Data updated 2026-11-12
This study is looking at how certain leukemia stem cells survive and resist treatment in acute myeloid leukemia, especially focusing on their need for protein production, to find new ways to help patients by targeting these cells more effectively.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 21, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $451,648 |
| NIH project number | 5R37CA273232-02 |
| Project ID | NIH-10932968 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with acute myeloid leukemia, particularly those with high-risk genetic subtypes.
✕Less likely to help
Patients with other types of leukemia or those who do not have acute myeloid leukemia may not benefit from this research.
What this research studies
This research investigates the mechanisms that allow leukemia stem cells (LSCs) to survive and resist treatment in acute myeloid leukemia (AML). By focusing on the regulation of protein synthesis, the study aims to identify specific genetic subtypes of LSCs that rely on this process for their self-renewal. The researchers will explore whether LSCs from high-risk types of AML are more dependent on regulated protein synthesis and will test a new therapeutic approach that targets this dependency. The ultimate goal is to develop effective therapies that can eliminate LSCs and improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively target and eradicate leukemia stem cells, improving survival rates for patients with AML.
How similar studies have gone: Previous research has shown promise in targeting cancer stem cells, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Chung, Stephen Shiu-Wah — Ut Southwestern Medical Center
- Study coordinator: Chung, Stephen Shiu-Wah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.