Understanding how leukemia progresses in patients
Identifying the mechanisms of leukemia progression
This study is looking at how genes affect the growth of leukemia in both kids and adults, using special tools and samples to find out what makes the disease different in each age group, with the hope of discovering new ways to treat or prevent it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10920372 on NIH RePORTER |
What this research studies
This research investigates the genetic mechanisms that lead to the progression of leukemia, particularly focusing on both pediatric and adult cases. By utilizing advanced techniques like CRISPR/Cas9 screening and studying animal models alongside patient samples, the research aims to identify key genetic events that contribute to the development of acute myeloid leukemia. The goal is to compare how blood disorders evolve in children versus adults and to explore potential therapies that could prevent or treat these conditions effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with acute myeloid leukemia or related blood disorders, particularly those under 21 years old.
Not a fit: Patients with non-leukemic blood disorders or those over 21 years old may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent the progression of leukemia and improve treatment outcomes for patients.
How similar studies have performed: Previous research has shown success in understanding genetic mechanisms in leukemia, making this approach both relevant and promising.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Crispino, John D — St. Jude Children's Research Hospital
- Study coordinator: Crispino, John D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.