Understanding how leukemia interacts with T cells in the tumor environment
Elucidating Human Leukemia and T Cell Interactions within the Tumor Microenvironment
['FUNDING_CAREER'] · UNIVERSITY OF TX MD ANDERSON CAN CTR · NIH-10816553
This study is looking at how leukemia cells and immune cells called T cells work together in the body, especially to see how this affects the success of stem cell transplants, with the goal of finding better ways to help leukemia patients respond to treatment.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TX MD ANDERSON CAN CTR (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10816553 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions between leukemia cells and T cells within the tumor microenvironment, particularly focusing on how these interactions affect the success of allogeneic stem cell transplantation. The study employs advanced techniques like single-cell RNA sequencing to analyze different types of exhausted T cells and their roles in responding to treatment. By identifying specific gene regulatory networks that influence these interactions, the research aims to uncover mechanisms that could improve treatment outcomes for patients with leukemia.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing allogeneic stem cell transplantation for leukemia who may benefit from enhanced immune therapies.
Not a fit: Patients with leukemia who are not candidates for stem cell transplantation or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing the immune response against leukemia, potentially reducing relapse rates after stem cell transplantation.
How similar studies have performed: Previous research has shown promising results in understanding T cell exhaustion and its implications for cancer treatment, suggesting that this approach may yield valuable insights.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TX MD ANDERSON CAN CTR — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BACHIREDDY, PAVAN — UNIVERSITY OF TX MD ANDERSON CAN CTR
- Study coordinator: BACHIREDDY, PAVAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer