Understanding how leukemia develops to improve treatment strategies
Official title: State-transition and leukemia potential dynamics to inform disease evolution and adaptive therapy
Funded at Beckman Research Institute/city of Hope · NIH-10978047 · Data updated 2026-11-12
This study is looking at how acute myeloid leukemia (AML) changes over time by checking gene activity, so we can find important moments in the disease's progress that help create personalized treatment plans to improve outcomes for patients.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | September 19, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $590,960 |
| NIH project number | 1U01CA293853-01 |
| Project ID | NIH-10978047 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with acute myeloid leukemia, particularly those with the CBFB-MYH11 fusion gene.
✕Less likely to help
Patients with other types of leukemia or those without the specific genetic markers associated with this research may not benefit from this study.
What this research studies
This research investigates the progression of acute myeloid leukemia (AML) by analyzing changes in gene expression over time. Using a state-transition model, the study aims to identify critical points in disease development that can inform personalized treatment plans. By examining RNA sequencing data from a genetic model of AML, researchers hope to develop dynamic biomarkers that can guide adaptive therapies and overcome treatment resistance. The ultimate goal is to enhance patient outcomes through tailored therapeutic approaches.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for patients with acute myeloid leukemia.
How similar studies have gone: Previous research has shown promise in using transcriptome analysis to inform treatment strategies in leukemia, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Rockne, Russell Christian — Beckman Research Institute/city of Hope
- Study coordinator: Rockne, Russell Christian
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.