Understanding how leukemia cells communicate with immune cells during CAR T-cell therapy
Map Leukemia-immune Cell Talks with Nanoplasmon Ruler in CAR T-Cell Immunotherapy
This study is looking at how special immune cells called CAR T-cells interact with leukemia cells in patients with B-cell acute lymphoblastic leukemia, aiming to find better ways to make these treatments work more effectively and reduce side effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10875282 on NIH RePORTER |
What this research studies
This research investigates the interactions between leukemia cells and immune cells, specifically focusing on CAR T-cells that are engineered to target CD19 in patients with B-cell acute lymphoblastic leukemia (B-ALL). The study aims to develop a novel technique using a nanoplasmon ruler to monitor the real-time communication and cytokine secretion between these cells in the tumor microenvironment. By gaining insights into these interactions, the research seeks to improve the effectiveness of CAR T-cell therapy and address issues such as poor T-cell function and cytokine release syndrome. Patients may benefit from a better understanding of how to enhance CAR T-cell therapies for more effective treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with B-cell acute lymphoblastic leukemia who are considering or undergoing CAR T-cell therapy.
Not a fit: Patients with other types of leukemia or those who are not eligible for CAR T-cell therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved CAR T-cell therapies for patients with B-ALL, enhancing treatment efficacy and reducing side effects.
How similar studies have performed: Other research has shown promise in enhancing CAR T-cell therapies, but the specific approach of using a nanoplasmon ruler for real-time monitoring is relatively novel.
Where this research is happening
New York, United States
- New York University — New York, United States (Active)
Researchers
- Principal investigator: Chen, Weiqiang — New York University
- Study coordinator: Chen, Weiqiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.