Understanding how leptin affects bone loss from inflammation
The Role of Leptin in Inflammation-Driven Bone Loss
['FUNDING_R01'] · OREGON STATE UNIVERSITY · NIH-11063263
This research explores how a hormone called leptin, which helps manage energy, also plays a part in bone loss caused by inflammation, especially as we age.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON STATE UNIVERSITY (nih funded) |
| Locations | 1 site (CORVALLIS, UNITED STATES) |
| Trial ID | NIH-11063263 on ClinicalTrials.gov |
What this research studies
We know that leptin is important for healthy bones, but it can also contribute to bone problems, particularly when there's ongoing inflammation. This project aims to understand the exact ways leptin acts on immune cells to either help or harm bone health. We want to find out if leptin signaling in immune cells is essential for normal bone growth and turnover, but also if it speeds up bone loss when inflammation is present. By understanding these mechanisms, we hope to uncover new ways to protect bones from inflammation-related damage.
Who could benefit from this research
Good fit: This foundational research focuses on the biological mechanisms of bone loss, and while it uses animal models, its findings could eventually benefit adults experiencing inflammation-driven bone loss.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention would not benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for preventing or treating bone loss in people experiencing chronic inflammation or aging-related bone conditions.
How similar studies have performed: This project builds upon strong preliminary data, suggesting that previous work has provided a solid foundation for these specific hypotheses.
Where this research is happening
CORVALLIS, UNITED STATES
- OREGON STATE UNIVERSITY — CORVALLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: IWANIEC, URSZULA T — OREGON STATE UNIVERSITY
- Study coordinator: IWANIEC, URSZULA T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.