Understanding how lentiviruses infect immune cells
Lentivirus Replication Strategy and Pathogenesis
['FUNDING_R01'] · EMORY UNIVERSITY · NIH-11063256
This study is looking at how HIV and similar viruses manage to infect immune cells, especially focusing on how they get around the body's defenses, with the hope of finding better treatments for these infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11063256 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which lentiviruses, such as HIV, infect different types of immune cells, particularly focusing on CD4+ T cells and myeloid cells. The study aims to uncover how these viruses can overcome cellular defenses that restrict their replication, specifically looking at the role of a protein called SAMHD1 that limits the availability of building blocks for viral DNA synthesis. By exploring these viral strategies, the research seeks to provide insights that could lead to improved treatments for infections caused by lentiviruses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV or at risk of HIV infection, particularly those with compromised immune systems.
Not a fit: Patients who are not infected with lentiviruses or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating HIV and other lentivirus infections.
How similar studies have performed: Previous research has shown success in understanding viral mechanisms of infection, suggesting that this approach could yield valuable insights.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIM, BAEK — EMORY UNIVERSITY
- Study coordinator: KIM, BAEK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.