Understanding how lens proteins focus light in the eye
Official title: Probing the molecular basis of refractive index in lens proteins
Funded at University of California-Irvine · NIH-11002284 · Data updated 2026-11-12
This study is looking at special proteins in the eye lens that help us see clearly, to learn how they stay stable and work well over time, especially when it comes to cataracts, with the hope of finding better ways to treat this common eye condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $178,224 |
| NIH project number | 5R21EY035792-02 |
| Project ID | NIH-11002284 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of developing cataracts or those with existing cataracts.
✕Less likely to help
Patients with eye conditions unrelated to cataracts or those who have already undergone cataract surgery may not benefit from this research.
What this research studies
This research investigates the proteins in the eye lens, known as crystallins, which are crucial for focusing light onto the retina. It aims to understand how these proteins maintain their refractive properties and stability over time, particularly in the context of cataracts. By examining the three-dimensional structures and interactions of these proteins, the study will measure how their composition affects their ability to bend light. The findings could lead to insights that improve our understanding of cataract formation and potential treatments.
Why it matters
Potential benefit: If successful, this research could lead to better treatments or preventive strategies for cataracts, enhancing vision health.
How similar studies have gone: Previous research has shown promising results in understanding protein interactions in the eye, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Martin, Rachel Wagner — University of California-Irvine
- Study coordinator: Martin, Rachel Wagner
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.