Understanding how lectins affect the human microbiome and developing new treatments.
Official title: Characterization of lectins to understand human microbiome functions and develop live biotherapeutics
Funded at Icahn School of Medicine at Mount Sinai · NIH-11041142 · Data updated 2026-11-12
This study is looking at a special protein called Cbeg5 to see how it affects the way our immune cells interact with the bacteria in our gut, which could lead to new treatment options for people with inflammatory bowel disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $371,800 |
| NIH project number | 5R01DK135675-03 |
| Project ID | NIH-11041142 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from inflammatory bowel disease or those interested in the health of their microbiome.
✕Less likely to help
Patients with conditions unrelated to microbiome function or those not affected by inflammatory bowel disease may not benefit from this research.
What this research studies
This research investigates the role of lectins, which are carbohydrate-binding proteins, in regulating interactions between human cells and the microbiome. By studying a specific lectin called Cbeg5, the research aims to uncover how it influences immune cell behavior and microbiome balance. The project will explore the potential of Cbeg5 as a therapeutic option for conditions like inflammatory bowel disease, utilizing advanced techniques in bioinformatics and cellular analysis. Patients may benefit from insights into how their microbiome functions and new treatment options that arise from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies for inflammatory bowel disease and improve our understanding of microbiome health.
How similar studies have gone: Previous research has shown promise in using lectins for therapeutic discovery, indicating that this approach may yield significant insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Cohen, Louis Jared — Icahn School of Medicine at Mount Sinai
- Study coordinator: Cohen, Louis Jared
Related research
Other NIH-funded projects on the same topics.
-
Improving Breast Cancer Guideline Adherence in Nigeria
Aimed at helping doctors in Nigeria follow international guideline-based breast cancer care to improve outcomes for women with breast cancer.
-
Genetically Validated PCOS Subtypes for Better Diagnosis and Risk Stratification
Aimed at women with polycystic ovary syndrome (PCOS), this project uses genetic data and patient characteristics to define distinct PCOS subtypes and improve how we diagnose and estimate risk.
-
Closed-loop control of interneuron timing to influence seizures and memory in epilepsy
A study tests a brain-quieting system that uses light to precisely time certain brain cells in epilepsy-prone mice to see if this can lessen seizures and improve memory.
-
Understanding why some brain regions and cells accumulate tau in Alzheimer’s and related diseases
Researchers are studying why certain brain areas and neuron types accumulate tau protein in Alzheimer’s and related conditions, and how this leads to brain changes and symptoms.
-
Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
-
Aging and brain injury connection: learning how late-life TBI relates to Alzheimer’s and related dementias
This grant looks at whether traumatic brain injuries in people 65 and older are linked to Alzheimer’s disease and related dementias, using a large, harmonized set of long-term aging studies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.