Understanding how LDL cholesterol affects blood clotting in hemophilia A
Official title: The role of LDL in hemostasis
Funded at Medical College of Wisconsin · NIH-11131984 · Data updated 2026-11-12
This study is looking at how LDL cholesterol affects blood clotting in people with hemophilia A, a condition that makes it hard for them to stop bleeding, to help find better ways to manage their bleeding issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | June 1, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $737,111 |
| NIH project number | 1R01HL174609-01A1 |
| Project ID | NIH-11131984 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with hemophilia A, particularly those with varying severities of the condition.
✕Less likely to help
Patients without hemophilia A or those with other bleeding disorders unrelated to LDL cholesterol may not benefit from this research.
What this research studies
This research investigates the relationship between low-density lipoprotein (LDL) cholesterol and blood clotting in patients with hemophilia A, a hereditary bleeding disorder. The study aims to uncover how LDL influences hemostasis and thrombosis, particularly in patients with varying levels of coagulation factor VIII (FVIII). By examining the interactions between LDL and key proteins involved in blood clotting, the research seeks to clarify the mechanisms behind bleeding severity in hemophilia A patients. This could lead to new insights into treatment strategies that improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of bleeding episodes in hemophilia A patients.
How similar studies have gone: Previous research has indicated potential links between LDL cholesterol and blood clotting mechanisms, suggesting that this area of investigation may yield valuable insights.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Zheng, Ze — Medical College of Wisconsin
- Study coordinator: Zheng, Ze
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.