Understanding how Ldb1 affects gene expression in red blood cell development
Official title: Investigating the role of Ldb1 in chromatin architecture and transcription during erythroid cell state transitions
Funded at University of Pennsylvania · NIH-10821758 · Data updated 2026-11-12
This study is looking at how a protein called Ldb1 helps organize the DNA in red blood cells, which is important for making sure the right genes are turned on as these cells develop, and it will also see what happens when Ldb1 is missing.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31DK136200-01A1 |
| Project ID | NIH-10821758 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to blood cell development or disorders affecting erythropoiesis.
✕Less likely to help
Patients with unrelated health conditions or those not experiencing issues with blood cell development may not benefit from this research.
What this research studies
This research investigates the role of a protein called Ldb1 in shaping the structure of chromatin, which is crucial for regulating gene expression during the development of red blood cells. By using a specific cellular model, the researchers will explore how Ldb1 influences long-range interactions between regulatory elements and target genes throughout the maturation process of these cells. They will also examine what happens when Ldb1 is depleted, providing insights into its importance for maintaining proper chromatin architecture and gene expression profiles during red blood cell differentiation.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of blood cell development and potential new treatments for blood disorders.
How similar studies have gone: While the specific role of Ldb1 in chromatin architecture is less explored, similar studies on chromatin dynamics have shown promising results in understanding gene regulation.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Aboreden, Nicholas — University of Pennsylvania
- Study coordinator: Aboreden, Nicholas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.