Understanding how latrophilins help form connections between brain cells
Latrophilin Function in Synapse Formation
This study is looking at how certain molecules in the brain help form connections between nerve cells, which is important for understanding conditions like mental health disorders, and it hopes to find new ways to help people with these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11080380 on NIH RePORTER |
What this research studies
This research investigates the role of latrophilins, a type of adhesion molecule, in the formation of synapses, which are the connections between neurons in the brain. By examining how these molecules contribute to the assembly and specificity of synapses, the study aims to uncover the underlying mechanisms that govern neural circuit architecture. The research will utilize advanced techniques to analyze the signaling pathways and interactions involved in synapse formation, particularly in the context of neuropsychiatric disorders linked to genetic variations in latrophilin genes. Patients may benefit from insights gained about the biological processes that could lead to new therapeutic strategies for these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neuropsychiatric disorders or those with genetic variations affecting latrophilin function.
Not a fit: Patients without neuropsychiatric disorders or those not affected by genetic variations in latrophilins may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neuropsychiatric disorders by improving our understanding of synapse formation.
How similar studies have performed: Other research has shown promising results in understanding synaptic mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Sudhof, Thomas C. — Stanford University
- Study coordinator: Sudhof, Thomas C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.