Understanding how large oncosomes contribute to prostate cancer growth and spread
Molecular Mechanisms of Large Oncosome-Induced Prostate Cancer Progression and Metastasis
This study is looking at how tiny particles made by prostate cancer cells, called oncosomes, might help the cancer grow and spread, and it’s for anyone interested in understanding more about prostate cancer and finding better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10704523 on NIH RePORTER |
What this research studies
This research investigates the role of large oncosomes, which are specialized extracellular vesicles produced by prostate cancer cells, in promoting cancer progression and metastasis. By analyzing how these oncosomes interact with surrounding cells, particularly fibroblasts, the study aims to uncover the molecular mechanisms that drive tumor growth and resistance to treatment. The research involves collecting and analyzing patient samples to correlate oncosome levels with cancer progression, as well as conducting laboratory experiments to observe the effects of oncosomes on cell behavior. This approach could lead to new insights into how prostate cancer develops and spreads, potentially informing future treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are men diagnosed with prostate cancer, particularly those who have developed resistance to castration therapy.
Not a fit: Patients with early-stage prostate cancer who have not yet undergone treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for preventing or slowing the progression of prostate cancer.
How similar studies have performed: Previous research has shown that understanding the role of extracellular vesicles in cancer can lead to significant advancements in treatment strategies, suggesting that this approach has potential for success.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Di Vizio, Dolores — Cedars-Sinai Medical Center
- Study coordinator: Di Vizio, Dolores
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.