Understanding how large molecules move through the nuclear pore complex in cells
Structure-function mapping of large cargo transport through the nuclear pore complex
['FUNDING_FELLOWSHIP'] · ROCKEFELLER UNIVERSITY · NIH-11249765
This study is looking at how big molecules like proteins and RNA move in and out of the cell's nucleus, which is important for keeping our cells healthy, and the findings could help us understand diseases better.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ROCKEFELLER UNIVERSITY (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11249765 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which large molecules, such as proteins and RNA, are transported through the nuclear pore complex (NPC) that surrounds the cell nucleus. By using advanced imaging techniques, the team aims to visualize the structure and function of the NPC in both its inactive and active states. This study will help clarify how these large cargoes can pass through the narrow channels of the NPC, which is crucial for maintaining cellular function and communication. Patients may benefit from insights gained into cellular transport processes that could impact various diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with conditions that involve cellular transport issues, such as certain cancers or genetic disorders.
Not a fit: Patients with conditions unrelated to cellular transport mechanisms may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to cellular transport dysfunction.
How similar studies have performed: Other research has shown success in understanding cellular transport mechanisms, making this approach a continuation of established scientific inquiry.
Where this research is happening
NEW YORK, UNITED STATES
- ROCKEFELLER UNIVERSITY — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CAFFALETTE, CHRISTOPHER ALPERT — ROCKEFELLER UNIVERSITY
- Study coordinator: CAFFALETTE, CHRISTOPHER ALPERT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.