Understanding how large molecules move through the nuclear pore complex in cells
Official title: Structure-function mapping of large cargo transport through the nuclear pore complex
Funded at Rockefeller University · NIH-10831782 · Data updated 2026-11-12
This study is looking at how big molecules like proteins and RNA move in and out of the cell's nucleus, which is important for keeping our DNA safe, and it uses special imaging tools to see how the transport system works.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $76,756 |
| NIH project number | 1F32GM153164-01 |
| Project ID | NIH-10831782 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve cellular transport issues, such as specific types of cancer or genetic disorders affecting protein transport.
✕Less likely to help
Patients with conditions unrelated to cellular transport mechanisms or those not involving the nuclear pore complex may not benefit from this research.
What this research studies
This research investigates the mechanisms by which large cargoes, such as proteins and RNA, are transported through the nuclear pore complex (NPC) that regulates the flow of information in and out of the cell nucleus. By examining the structure and function of the NPC, the research aims to uncover how these large molecules can pass through the nuclear envelope, which serves as a protective barrier for DNA. The study employs advanced imaging techniques to visualize the NPC in different states, providing insights into its dynamic behavior during transport processes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting and treating diseases related to cellular transport dysfunction, including certain cancers.
How similar studies have gone: Previous research has shown promising results in understanding cellular transport mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Caffalette, Christopher Alpert — Rockefeller University
- Study coordinator: Caffalette, Christopher Alpert
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.