Understanding how large molecules interact in living cells
Official title: Modeling of macromolecular interactions in the cell
Funded at University of Kansas Lawrence · NIH-11011592 · Data updated 2026-11-12
This study is looking at how big molecules in our cells work together, which could help scientists create better drugs for patients by understanding how proteins interact.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Lawrence NIH-funded |
| Lab location | 1 site (Lawrence, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $294,147 |
| NIH project number | 1R35GM156453-01 |
| Project ID | NIH-11011592 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with conditions that involve protein interactions, such as certain cancers or genetic disorders.
✕Less likely to help
Patients with conditions unrelated to macromolecular interactions or those not requiring drug interventions may not receive benefit from this research.
What this research studies
This research focuses on modeling the interactions of macromolecules within living cells using advanced techniques. By combining docking methods with biomolecular simulations, the project aims to accurately capture the dynamics and kinetics of these interactions. Patients may benefit from insights gained about how proteins and other macromolecules function together, which could inform drug design and targeting strategies. The research will involve characterizing energy landscapes of macromolecules and developing public resources based on the findings.
Why it matters
Potential benefit: If successful, this research could lead to improved drug design and targeting strategies that enhance treatment effectiveness for various diseases.
How similar studies have gone: Other research has shown success in using advanced modeling techniques for macromolecular interactions, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
-
University of Kansas Lawrence
Lawrence, United States Active
Researchers
- Principal investigator: Vakser, Ilya — University of Kansas Lawrence
- Study coordinator: Vakser, Ilya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.