Understanding how large molecular complexes regulate gene transcription
Structure, Function, and Dynamics of Macro-molecular Complexes that Execute and Regulate Genome Function
This study is looking at how big molecular groups work with an important enzyme to help turn genes into messages that our cells can read, which could help us understand gene regulation better and lead to new treatments for diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-11062467 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between large molecular complexes (LMCs) and RNA Polymerase II, which are crucial for the transcription of genes into mRNA. By employing innovative techniques such as GFP aptamer-based purification and advanced imaging methods like Mass Spectrometry and Cryo-Electron Microscopy, the study aims to uncover how these complexes function and interact under natural conditions. This could lead to a better understanding of gene regulation and its implications for various diseases. Patients may benefit from insights gained into the molecular mechanisms of transcription that could inform future therapies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic disorders or cancers related to transcriptional regulation.
Not a fit: Patients with conditions unrelated to genetic transcription or those not affected by molecular regulation may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding gene regulation, potentially impacting treatments for genetic disorders and cancers.
How similar studies have performed: Previous research has shown success in understanding molecular complexes in gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Lis, John T — Cornell University
- Study coordinator: Lis, John T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.