Understanding how large enzymes work at the atomic level
Official title: Atomic-level characterization of self-regulatory mechanisms in large multidomain enzymes
Funded at Iowa State University · NIH-11126017 · Data updated 2026-11-12
This study is looking at how certain important enzymes in our bodies and bacteria work, especially how their shape and movement change when they interact with other molecules, which could help us find better treatments for infections and metabolic issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa State University NIH-funded |
| Lab location | 1 site (Ames, United States) |
| Project start | September 1, 2019 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $363,522 |
| NIH project number | 5R35GM133488-08 |
| Project ID | NIH-11126017 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals suffering from bacterial infections or metabolic disorders.
✕Less likely to help
Patients with conditions unrelated to bacterial metabolism or enzyme dysfunction may not receive any benefit from this research.
What this research studies
This research investigates the intricate mechanisms by which large multidomain enzymes function, focusing on how their structure and flexibility are influenced by the binding of cofactors and substrates. By employing advanced techniques such as NMR and other biophysical tools, the study aims to uncover the relationship between enzyme motion and its activity, particularly in enzymes crucial for human and bacterial metabolism. Patients may benefit from insights gained into these enzymes, which could lead to improved treatments for bacterial infections and metabolic disorders.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective antibiotics and therapies for metabolic diseases.
How similar studies have gone: Previous research has shown success in understanding smaller proteins, but this approach to large multidomain enzymes is relatively novel and untested.
Where this research is happening
-
Iowa State University
Ames, United States Active
Researchers
- Principal investigator: Venditti, Vincenzo — Iowa State University
- Study coordinator: Venditti, Vincenzo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.