Understanding how large DNA viruses interact and evolve with their host organisms
Coevolutionary Dynamics and Gene Exchange Between Nucleo-Cytoplasmic Large DNA Viruses and Eukaryotes
This study looks at how big DNA viruses have changed and adapted alongside living things like algae and animals over millions of years, and it aims to understand how these viruses affect the health and functions of their hosts, including how they respond to infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Polytechnic Inst and St Univ NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project ID | NIH-10893452 on NIH RePORTER |
What this research studies
This research investigates the complex relationships between large DNA viruses and their eukaryotic hosts, focusing on how these viruses have co-evolved with organisms like algae and animals over millions of years. By analyzing the genetic exchanges and evolutionary dynamics, the study aims to uncover how these viruses influence host biology, including immune responses and cellular functions. The research employs advanced genomic techniques to explore the viral mimicry genes that these viruses have acquired from their hosts, which may play critical roles in various biological processes.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with conditions related to viral infections or those involved in studies of eukaryotic organisms, such as algae.
Not a fit: Patients with unrelated health conditions or those not affected by viral infections may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of viral infections and lead to improved strategies for managing diseases caused by these viruses.
How similar studies have performed: Previous research has shown promising results in understanding viral interactions with hosts, indicating that this approach has potential for significant discoveries.
Where this research is happening
Blacksburg, United States
- Virginia Polytechnic Inst and St Univ — Blacksburg, United States (Active)
Researchers
- Principal investigator: Aylward, Frank O'neill — Virginia Polytechnic Inst and St Univ
- Study coordinator: Aylward, Frank O'neill
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.