Understanding how large brain size relates to autism spectrum disorder
Mechanisms by Which Macrocephaly Underlies Autism Spectrum Disorder
['FUNDING_R21'] · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · NIH-10909012
This study is looking at how having a larger brain might be connected to autism, especially by exploring certain genes that could affect brain growth and behavior, and it uses animal models to help understand these links better.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CONNECTICUT SCH OF MED/DNT (nih funded) |
| Locations | 1 site (FARMINGTON, UNITED STATES) |
| Trial ID | NIH-10909012 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between macrocephaly, or enlarged brain size, and autism spectrum disorder (ASD). It focuses on how excessive proliferation of brain cells in individuals with ASD may contribute to their symptoms. By studying specific genes like ASPM, which is linked to brain size and function, the research aims to uncover the biological mechanisms that underlie ASD. The approach includes using animal models to observe behaviors and brain development associated with these genetic changes.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and adults diagnosed with autism spectrum disorder, particularly those exhibiting macrocephaly.
Not a fit: Patients without a diagnosis of autism spectrum disorder or those not exhibiting macrocephaly may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the biological causes of autism, potentially informing better treatment strategies.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors related to brain size and autism, suggesting that this approach may yield valuable insights.
Where this research is happening
FARMINGTON, UNITED STATES
- UNIVERSITY OF CONNECTICUT SCH OF MED/DNT — FARMINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BAE, BYOUNG-IL — UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
- Study coordinator: BAE, BYOUNG-IL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autism Spectrum Disorder patient, Autistic Disorder