Understanding how large animal hearts can regenerate after injury
Deciphering the Neonatal Cardiac Regenerative Potential and Regulators in Large Animals
This study is looking at how baby hearts in large animals can heal after injuries like heart attacks, to find out when and how they can grow back healthy heart cells, which could help create new treatments for heart failure in both kids and adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10442732 on NIH RePORTER |
What this research studies
This research investigates the regenerative potential of neonatal hearts in large mammals, aiming to understand if they can fully recover from injuries like heart attacks. The team will explore the timing of this regenerative ability and identify the biological factors that control heart cell growth. By modifying these factors, they hope to enhance heart repair mechanisms, which could lead to new treatments for heart failure in both children and adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from heart failure or those at risk of heart-related conditions.
Not a fit: Patients with chronic heart conditions that are not amenable to regenerative therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to groundbreaking therapies that enable heart regeneration, significantly improving outcomes for patients with heart failure.
How similar studies have performed: Previous research has shown promising results in neonatal heart regeneration, but this specific approach in large mammals is relatively novel.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Zhang, Jianyi — University of Alabama at Birmingham
- Study coordinator: Zhang, Jianyi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.