Understanding how Lamin A/C affects muscle cell function as we age
Official title: Lamin A/C is required for maintaining subsynaptic myonuclei integrity
Funded at University of Michigan at Ann Arbor · NIH-10890934 · Data updated 2026-11-12
This study is looking at how a protein called Lamin A/C helps keep muscle cell nuclei healthy, especially as we age, and how changes in these nuclei might affect our ability to move and stay active as we get older.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $52,082 |
| NIH project number | 1R36AG087309-01 |
| Project ID | NIH-10890934 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over the age of 21 who are experiencing age-related muscle decline or mobility issues.
✕Less likely to help
Patients who are younger than 21 or do not have any mobility issues related to aging may not benefit from this research.
What this research studies
This research investigates the role of Lamin A/C in maintaining the integrity of specific nuclei in muscle cells that are crucial for muscle function. It focuses on how age-related changes in these nuclei may contribute to the degeneration of neuromuscular junctions, which are essential for muscle contraction and movement. By examining the relationship between these nuclei and muscle health, the study aims to uncover mechanisms that lead to decreased mobility and physical frailty in older adults. The approach includes analyzing muscle samples and gene expression to understand the underlying biological processes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating muscle degeneration and improving mobility in older adults.
How similar studies have gone: Previous research has shown varying results regarding the role of muscle nuclei in aging, indicating that this area of study is both relevant and necessary for further exploration.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Ruiz, Lloyd Phillip — University of Michigan at Ann Arbor
- Study coordinator: Ruiz, Lloyd Phillip
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.