Understanding how L1 retrotransposons affect mammalian biology
In vivo biology of mammalian L1 retrotransposition
This study is looking at how certain genetic elements called LINE-1 might affect health issues like cancer, infertility, and aging, especially in male reproduction, to find ways to help prevent problems related to infertility.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-10995315 on NIH RePORTER |
What this research studies
This research investigates the role of Long Interspersed Nuclear Elements (LINEs), specifically LINE-1 (L1), in mammalian genomes and their potential link to various health issues such as cancer, infertility, and aging. The study aims to explore how L1 elements mutate genomes and whether their unchecked expression contributes to these disorders. Using mouse genetics, the researchers will examine the interaction between L1 and cellular factors involved in its retrotransposition, particularly focusing on the male germ line. By understanding these mechanisms, the research hopes to identify ways to mitigate germ line defects associated with infertility.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing infertility or related reproductive issues, as well as those with conditions associated with abnormal L1 activity.
Not a fit: Patients with conditions unrelated to L1 retrotransposition or those not experiencing infertility may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into infertility and other disorders linked to L1 retrotransposition, potentially informing future treatments.
How similar studies have performed: While the role of L1 in various disorders is known, this specific approach using mouse genetics to explore its biological relevance in vivo is relatively novel.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Han, Jeffrey S — Tulane University of Louisiana
- Study coordinator: Han, Jeffrey S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.