Understanding how kynurenine affects muscle and bone strength as we age
Kynurenine accumulation drives loss of muscle and bone function with aging
This research explores how a natural body chemical called kynurenine might contribute to weaker muscles and bones in older adults.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-11103291 on NIH RePORTER |
What this research studies
As we get older, many of us experience a decline in muscle and bone strength, which can lead to falls and fractures. This important research aims to understand why this happens at a molecular level. We are looking into how increased levels of a substance called kynurenine, found in the body, might activate a specific receptor (AhR) and contribute to this age-related weakening of muscles and bones. By understanding these processes, we hope to find new ways to help maintain strength and prevent injuries in older age.
Who could benefit from this research
Good fit: This research is relevant to older adults experiencing or at risk of muscle and bone weakness, falls, and fractures.
Not a fit: Patients not experiencing age-related muscle and bone loss would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments or strategies to prevent or reverse age-related muscle and bone loss, improving quality of life for older adults.
How similar studies have performed: This project builds upon previous findings from the same research team, which identified kynurenine's role and its association with frailty and fractures in older patients.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Isales, Carlos M. — Augusta University
- Study coordinator: Isales, Carlos M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.